Why Mainstream Conventional treatment is NOT the best option and may worsen knee pain and osteoarthritis (2023)

Regenerative medicine treatment with stem cells and platelet rich plasma (PRP) has been in medical science for years. Its best results are seen in conditions like knee osteoarthritis, shoulder osteoarthritis and shoulder rotator cuff tears along with many back pain related conditions. But there is always a reluctance to prioritize new treatments over conventional treatments. Below lies the answer justified by recent studies that highlight PRP and regenerative medicine treatment over conventional ones. Let’s find out why you should seek regenerative medicine treatment now!

Surprising data from most recent studies:

(Video) Is knee arthritis really the cause of your knee pain?

The conventional treatments for knee osteoarthritis are NSAIDs such as Motrin, Advil, Aleve, Celebrex, and corticosteroid injections. But do you think that these options are still the best for arthritis? These medicines may relieve the symptoms of arthritis, like knee pain, but sadly, we have evidence for you that these treatment options may severely affect knee osteoarthritis instead of treating it. Data from the Osteoarthritis Initiative revealed that NSAIDs are not what people think of them. Those who took NSAIDs for knee arthritis had worsened inflammation and cartilage quality, shown at the four-year follow-up, compared to control patients. In the end, patients might have experienced more intense knee pain (3,4) due to poor cartilage development. This was a very profound finding as it showed NSAIDS resulted in more inferior cartilage development that led to accelerated damage when compared to the population of people who did not use NSAIDS.

More studies highlighting damaging effects of steroid injections:

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In another study, where the patients had gotten steroid injections for knee osteoarthritis, the result was not very promising. A total of 44 patients received corticosteroid injections, and 26 got hyaluronic acid shots. When compared with a control group through MRI, it was found that steroid shots caused arthritis progression after 2 years of follow-up. The hyaluronic acid group decreased the progression of arthritis. Overall, it was concluded that corticosteroids were proven to be an inferior option (5).

Another OAI database study showed that corticosteroids provided no benefit in treating knee osteoarthritis. The subjects were divided based on corticosteroid injections, hyaluronic acid injections, and a controlled group. The same grading system was used for each group. After 3 years, the results were compared with the help of X-rays. The ones with steroid shots showed more disease progression than those with hyaluronic acid and no treatment (5).

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What we know now:

These findings are not all new. We have known about the effect of steroid injections on knee cartilage through various animal studies and randomized trials for some time. However, the adverse effects of NSAIDs on knee osteoarthritis are new; we can say that all of these findings may reject the idea of the conventional treatment plan for knee osteoarthritis pain (6-8).

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So, the question is, what will you do now? A hyaluronic acid injection may seem a good choice, but studies regarding it are somewhat weak and the benefit for some is very short lived. There is a chance that the shot doesn’t get to the desired place inside the joint, making HA ineffective. Another problem with HA is that its effect slowly tapers off with time, of which the cause is unknown. So, you are left with PRP, which has shown the most positive effects than any other treatment (9-11).

PRP helps you with knee pain to an extent you cannot imagine. Its cost is not very critical, and it has the potential to control the symptoms of knee osteoarthritis. Many physicians have been using NSAIDs and steroid injections for knee pain, but the harm these treatments cause is not worth the long-term deterioration to cartilage integrity. With these findings, we have evolved from these conventional treatments to PRP and stem cells (12-15).

(Video) Advanced Treatments for Knee Pain

Overall, the evidence shows that patients with knee osteoarthritis must constantly change their way to stop the disease progression (16-19). With a very large body of evidence supporting the use of orthobiologics such as PRP, mesenchymal stem cells, alpha-2 macroglobulin (A2M) and extracellular matrix, it seems there are finally treatments available that provide a clear path to better treatment with no damaging longterm cost. Many patients are finding that these lead to better activity levels, lower pain, improved sleep and happier life. These have been shown to help with knee meniscus tears, shoulder rotator cuff tears, lower back pain, osteoarthritis of various joints and tennis or golfers elbow.

At Spectrum Stem Cell and Regenerative Medicine Center we strive to provide the most advanced treatment for many orthopedic injuries and chronic deteriorating conditions. At our clinic you know you will be getting the best treatment with the best results, we stay up to date!

(Video) How to Fix Knee Pain for Good (AT HOME!)


  1. Regenerative medicine in the field of pain medicine: Prolotherapy, platelet-rich plasma therapy, and stem cell therapy—Theory and evidence. Techniques in Regional Anesthesia and Pain Management. 2011;15(2):74-80.
  2. Ramaswamy Reddy SH, Reddy R, Babu NC, Ashok GN. Stem-cell therapy and platelet-rich plasma in regenerative medicines: A review on pros and cons of the technologies. J Oral Maxillofac Pathol. 2018;22(3):367-374.
  3. America (RSNA) RS of N. Nsaids may worsen arthritis inflammation.
  4. Nancy Garrick DD. Osteoarthritis initiative. National Institute of Arthritis and Musculoskeletal and Skin Diseases.
  5. America (RSNA) RS of N. Steroid injections worsen knee arthritis.
  6. Wyles CC, Houdek MT, Wyles SP, Wagner ER, Behfar A, Sierra RJ. Differential cytotoxicity of corticosteroids on human mesenchymal stem cells. Clin Orthop Relat Res. 2015;473(3):1155-1164.
  7. Dragoo JL, Danial CM, Braun HJ, Pouliot MA, Kim HJ. The chondrotoxicity of single-dose corticosteroids. Knee Surg Sports Traumatol Arthrosc. 2012;20(9):1809-1814.
  8. McAlindon TE, LaValley MP, Harvey WF, et al. Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial. JAMA. 2017;317(19):1967-1975.
  9. Xing D, Wang B, Liu Q, et al. Intra-articular hyaluronic acid in treating knee osteoarthritis: a prisma-compliant systematic review of overlapping meta-analysis. Sci Rep. 2016;6:32790.
  10. Richette P, Chevalier X, Ea HK, et al. Hyaluronan for knee osteoarthritis: an updated meta-analysis of trials with low risk of bias. RMD Open. 2015;1(1):e000071.
  11. Pereira TV, Jüni P, Saadat P, et al. Viscosupplementation for knee osteoarthritis: systematic review and meta-analysis. BMJ. 2022;378.
  12. Raeissadat SA, Rayegani SM, Hassanabadi H, et al. Knee osteoarthritis injection choices: platelet- rich plasma (Prp) versus hyaluronic acid(A one-year randomized clinical trial). Clin Med Insights Arthritis Musculoskelet Disord. 2015;8:1-8.
  13. Montañez-Heredia E, Irízar S, Huertas PJ, et al. Intra-articular injections of platelet-rich plasma versus hyaluronic acid in the treatment of osteoarthritic knee pain: a randomized clinical trial in the context of the spanish national health care system. Int J Mol Sci. 2016;17(7):1064.
  14. Görmeli G, Görmeli CA, Ataoglu B, Çolak C, Aslantürk O, Ertem K. Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial. Knee Surg Sports Traumatol Arthrosc. 2017;25(3):958-965.
  15. Lana JFSD, Weglein A, Sampson SE, et al. Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee. J Stem Cells Regen Med. 2016;12(2):69-78.
  16. Tavassoli M, Janmohammadi N, Hosseini A, Khafri S, Esmaeilnejad-Ganji SM. Single- and double-dose of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: A randomized controlled trial. World J Orthop. 2019;10(9):310-326.
  17. Lin KY, Yang CC, Hsu CJ, Yeh ML, Renn JH. Intra-articular injection of platelet-rich plasma is superior to hyaluronic acid or saline solution in the treatment of mild to moderate knee osteoarthritis: a randomized, double-blind, triple-parallel, placebo-controlled clinical trial. Arthroscopy. 2019;35(1):106-117.
  18. Huang Y, Liu X, Xu X, Liu J. Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis : A prospective randomized controlled study. Orthopade. 2019;48(3):239-247.
  19. Di Martino A, Di Matteo B, Papio T, et al. Platelet-rich plasma versus hyaluronic acid injections for the treatment of knee osteoarthritis: results at 5 years of a double-blind, randomized controlled trial. Am J Sports Med. 2019;47(2):347-354.


What is the best treatment for severe osteoarthritis of the knee? ›

Non-steroidal anti-inflammatory drugs (NSAIDs)

Some topical NSAIDs are available without a prescription. They can be particularly effective if you have osteoarthritis in your knees or hands. As well as helping to ease pain, they can also help reduce any swelling in your joints.

What is the best treatment for pain when suffering with osteoarthritis? ›

Nonsteroidal anti-inflammatory drugs (NSAIDs).

Over-the-counter NSAIDs , such as ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve), taken at the recommended doses, typically relieve osteoarthritis pain. Stronger NSAIDs are available by prescription.

What nonpharmacologic treatment modalities should be recommended for osteoarthritis? ›

Nonpharmacologic complementary and integrative health treatments for OA include mind and body practices such as acupuncture, deep breathing, yoga, tai chi, meditation, massage, and relaxation techniques among others. Some encouraging research has been published on acupuncture, tai chi and yoga.

What is the best non surgical treatment for knee osteoarthritis? ›

The American Academy of Orthopedic Surgeons (AAOS) recommends strengthening exercises, low impact aerobic exercises, aquatic exercises, weight loss programs, and nonsteroidal anti-inflammatory agents (NSAIDs) (5).

What is the best option for end stage osteoarthritis? ›

Answer: Current treatments for end-stage arthritis (bone touching bone) are very limited and are mostly surgical options, i.e. joint replacement. Currently there is no effective way of replacing the cartilage that is damaged or worn out.

What is the new treatment for knee osteoarthritis? ›

New hydrogel injection for knee osteoarthritis offers patients a return to mobility without surgery. Safe and sustained pain relief with a single injection.

What is the new treatment for osteoarthritis 2022? ›

University of Oxford. "New drug offers hope for people with hand osteoarthritis: The drug talarozole -- which increases retinoic acid -- could be a promising new treatment for hand osteoarthritis." ScienceDaily. ScienceDaily, 21 December 2022.

What makes pain worse in osteoarthritis? ›

The main symptoms of osteoarthritis are pain and sometimes stiffness in the affected joints. The pain tends to be worse when you move the joint or at the end of the day. Your joints may feel stiff after rest, but this usually wears off fairly quickly once you get moving.

What should you not do with osteoarthritis of the knee? ›

High-impact sports

Avoid high-impact workouts and exercises if you have osteoarthritis of the knee, hip, or ankle. These activities often place stress on weight-bearing joints. Basketball, football, hockey, and soccer are all examples of high-impact sports.

What is the gold standard treatment for osteoarthritis? ›

Total joint arthroplasty (replacement) — Total joint arthroplasty (replacement) surgery is the gold standard treatment in patients with severe end-stage symptomatic osteoarthritis (OA) who have failed to respond to nonpharmacologic and pharmacologic management and who have significant impairment in their quality of ...

What physical therapy is good for osteoarthritis of the knee? ›

Manual therapy.

Physical therapists are trained in manual (hands-on) therapy. Your physical therapist will gently move your muscles, loosening them to gain more range of motion in your knee joint and increase your flexibility.

Which one is more effective for the clinical treatment of chronic pain in knee osteoarthritis radiofrequency Neurotomy of the Genicular nerves or intra articular injection? ›

This study demonstrated that genicular nerve RF neurotomy is a safe and efficient treatment modality and provides functional improvement along with an analgesia in patients with chronic knee OA.

Will osteoarthritis get worse without treatment? ›

Osteoarthritis is a long-term condition and cannot be cured, but it doesn't necessarily get any worse over time and it can sometimes gradually improve. A number of treatments are also available to reduce the symptoms. Mild symptoms can sometimes be managed with simple measures, including: regular exercise.

What is the best alternative to knee replacement? ›

Knee arthritis: 5 alternatives to knee replacement surgery
  1. Physical therapy. Knee arthritis typically makes the knee joint painful and stiff. ...
  2. Medications. ...
  3. Injections. ...
  4. Arthroscopic surgery. ...
  5. Osteotomy.
Sep 28, 2022

Is there a good alternative to knee replacement? ›

Cartilage Regeneration

There are several cartilage-regeneration techniques that you may consider and discuss with an orthopaedic surgeon. Autologous chondrocyte implantation (ACI), for example, involves taking a sample of your cartilage cells, growing them in a lab and then surgically replanting them in your knee.

When is it time to get a knee replacement? ›

Long-lasting pain isn't getting better.

If you've tried exercise, physical therapy, and pain medication but your pain isn't getting better, it may be time to consider knee replacement surgery. After knee replacement surgery, pain goes away for as many as 90-95 percent of younger patients.

What is the best medicine for knee pain in old age? ›

Over-the-counter medications — such as ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve) — may help ease knee pain. Some people find relief by rubbing the affected knee with creams containing a numbing agent, such as lidocaine, or capsaicin, the substance that makes chili peppers hot.

How many years does it take for osteoarthritis to progress? ›

Osteoarthritis is generally a slowly progressive disorder. However, at least 1 in 7 people with incident knee osteoarthritis develop an abrupt progression to advanced-stage radiographic disease, many within 12 months.

Why is there no treatment for osteoarthritis? ›

The reason for that is simple. “Once cartilage is gone, it's gone for good and there's no replacement that we know of,” Luk said. “All the medications that we have are only for temporary pain relief.”

Is Knee Replacement good for osteoarthritis? ›

Unfortunately, knee replacement surgery does not cure arthritis. Although it can correct the damage caused by arthritis and relieve the pain associated with the condition, it cannot make the arthritis go away.

What is the European treatment for osteoarthritis? ›

An acute flare of OA is usually treated with analgesics, non-steroidal anti-inflammatory drugs (NSAIDs) or an intraarticular injection with corticosteroids for fast symptom relief. For non-acute treatment symptomatic slow acting drugs for OA (SYSADOA) are available.

What is the new breakthrough in osteoarthritis? ›

A new study, published in Science Translational Medicine by researchers at the University of Oxford has identified that Talarozole, a drug that is known to increase retinoic acid, was able to prevent osteoarthritis (OA) in disease models.

What is the safest drug to take for osteoarthritis? ›

Generally, the first medication recommended for osteoarthritis treatment is acetaminophen. It relieves pain but does not reduce inflammation in the body. Acetaminophen is relatively safe, though taking more than the recommended dosage can damage your liver, according to the Food and Drug Administration (FDA).

How do you treat bone on bone knee pain without surgery? ›

Recommended Non-Surgical Treatment Options
  1. Bracing. We may suggest a knee brace to provide external stability to the knee joint. ...
  2. Injections and Infusions. Some medications can be injected directly into the knee to treat your pain. ...
  3. Lifestyle Modifications. ...
  4. Nutraceuticals. ...
  5. Pain Medications. ...
  6. Physical and Occupational Therapy.

How can I stop my osteoarthritis knee pain getting worse? ›

Management and Treatment
  1. Maintain a healthy weight.
  2. Exercise using low-impact activities (swimming, cycling) instead of high-impact activities (jogging, tennis). ...
  3. Wear shock-absorbing inserts in your shoes.
  4. Apply heat or ice to the area.
  5. Wear a knee sleeve or brace.
Oct 18, 2021

Should osteoarthritis hurt all the time? ›

Osteoarthritis affects each person differently. For some people, osteoarthritis is relatively mild and does not affect day-to-day activities. For others, it causes significant pain and disability. Joint damage usually develops gradually over years, although it could worsen quickly in some people.

Can gabapentin help osteoarthritis? ›

While gabapentin is generally not prescribed to treat arthritis, research has found it to help manage the effects of severe knee osteoarthritis (OA). There is no evidence showing it improves pain caused by autoimmune arthritis conditions such as rheumatoid arthritis and psoriatic arthritis , though.

What happens if the osteoarthritis of the knee is left untreated? ›

Osteoarthritis could lead to chondrolysis, which is a complete breakdown of the cartilage, leading to loose joint tissue material. Osteonecrosis, which is bone death, is another possible issue. Repeated stress or injury could cause stress fractures, which are hairline cracks in the bone near the affected joint.

What should you avoid if you have osteoarthritis? ›

5 Foods to Avoid
  • Red meat and fried foods. Fried foods and red meat contain high levels of advanced glycation end products (AGEs), which are known for stimulating inflammation. ...
  • Sugars. ...
  • Dairy. ...
  • Refined carbohydrates. ...
  • Alcohol and tobacco.
Dec 21, 2020

How can I stop my knee osteoarthritis from progressing? ›

Slowing Osteoarthritis Progression
  1. Maintain a Healthy Weight. Excess weight puts additional pressure on weight-bearing joints, such as the hips and knees. ...
  2. Control Blood Sugar. ...
  3. Get Physical. ...
  4. Protect Joints. ...
  5. Choose a Healthy Lifestyle.

Can turmeric cure osteoarthritis? ›

Turmeric's main active component — curcumin — is what gives the spice its yellow color. Curcumin has anti-inflammatory properties, making it a potential treatment for a number of health conditions, including reduced pain and increased ease of movement in people with osteoarthritis.

What is the second line treatment for osteoarthritis? ›

Duloxetine is a second-line agent for treatment of osteoarthritis of the knee that has not responded to acetaminophen or non-steroidal anti-inflammatory drugs (NSAIDs). What types of arthritis is duloxetine used for?

Are there any new treatments for osteoarthritis? ›

ACI has been shown to improve the symptoms of osteoarthritis, including pain and mobility. It can also slow or stop osteoarthritis developing, delaying or preventing the need for joint replacement surgery. This makes it particularly useful for younger people with early-stage osteoarthritis.

What is the most effective treatment for knee arthritis? ›

For mild symptoms, topical medications applied to the knees such as diclofenac gel relieve pain and have few adverse effects. Nonsteroidal anti-inflammatory medications such as ibuprofen and naproxen are the most effective oral medications for osteoarthritis.

Does physical therapy work on osteoarthritis on the knee? ›

Physical therapy can help to reduce the pain, swelling, and stiffness of knee osteoarthritis, and it can help improve knee joint function. It can also make it easier for you to walk, bend, kneel, squat, and sit.

Does physical therapy help severe osteoarthritis? ›

Physical therapist treatment has proven to be an effective treatment for OA, and may help you avoid surgery and use of prescription painkillers.

What is the best treatment for severe osteoarthritis? ›

Corticosteroids can ease inflammation and swelling and offer quick, short-term pain relief for people with OA. The benefit usually lasts several weeks to several months. Some people can get pain relief for 6 months or longer. These injections are usually given no more than three or four times a year in a single joint.

What is the most widely accepted approach to treating chronic pain conditions? ›

The pain medicine model is widely accepted and widely used. It is based upon the idea that pain is an acute, treatable disease. This approach usually begins with the primary care physician. Primary care physicians may make a referral to a pain specialist or pain clinic.

Which Nsaid is most effective in the treatment of hip or knee osteoarthritis? ›

Diclofenac 150 mg/d is the most effective NSAID for pain relief (about 14% more than placebo) in patients with hip or knee osteoarthritis (SOR: A, meta-analyses).

Can osteoarthritis be fixed without surgery? ›

NSAIDs, weight loss, intraarticular injections, and physical therapy have all been shown to be effective non-surgical treatment options for knee OA.

How can I live pain free with osteoarthritis? ›

Follow these tips to help you feel better and learn from people who have experienced chronic pain from arthritis.
  1. Take Your Medications. Prescription and over-the-counter drugs recommended by your doctor help control inflammation and pain. ...
  2. Manage Your Weight. ...
  3. Stay Active. ...
  4. Keep a Positive Attitude.

What happens if you need a knee replacement and don t get one? ›

What are the risks of delaying knee replacement surgery? Simply put, the longer you wait to get a knee replacement, the more wear and tear you put on your knees – and the longer you live with increasing pain, stiffness or mobility issues.

Do you need a knee replacement if you are bone on bone? ›

As knee arthritis progresses, the knee becomes much looser and more unstable. In some cases, this is mild. In other cases, it is substantial enough that cause the patient to fall. Patients who have bone-on-bone arthritis and are starting to fall because of it should strongly consider surgery.

At what age does Medicare stop paying for knee replacement? ›

There is no Medicare knee replacement age limit. However, in order for Medicare to pay for knee replacement surgery, you must be enrolled in Medicare and meet the Medicare Part A deductible. In 2022, the Medicare Part A deductible is $1,556 per benefit period.

What can be done for a knee that is bone on bone? ›

A total knee replacement is the most common knee replacement surgeries for bone-on-bone arthritis. This surgery involves resurfacing the ends of your knee joint bones, including the femur (or thigh bone) and tibia bone. This process is similar to capping a tooth.

What is the most prescribed medication for osteoarthritis? ›

Nonsteroidal anti-inflammatory drugs (NSAIDs) Nonsteroidal anti-inflammatory drugs (NSAIDs) treat pain. They also help to prevent painful inflammation and joint damage. They're the top choice of treatment for OA because they're effective and nonsedating.

What is the best painkiller for arthritis of the knee? ›

NSAIDs are the most effective oral medicines for OA. They include ibuprofen (Motrin, Advil) naproxen (Aleve) and diclofenac (Voltaren, others). All work by blocking enzymes that cause pain and swelling.

Do you need a knee replacement if you are bone-on-bone? ›

As knee arthritis progresses, the knee becomes much looser and more unstable. In some cases, this is mild. In other cases, it is substantial enough that cause the patient to fall. Patients who have bone-on-bone arthritis and are starting to fall because of it should strongly consider surgery.

Can you fix bone-on-bone in knee without surgery? ›

IMAC provides non-surgical treatments to bring stability back into the knee joint to signal the body to stop the arthritis process. Physical therapists at our centers often use high-level bracing to help bring stability and correct alignment to the knee joint.

What is the downside of knee replacement? ›

Disadvantages. Possible disadvantages of knee replacement surgery can include replacement joints wearing out over time, difficulties with some movements and numbness. We now know that knee replacements aren't so likely to be effective in the early stages of arthritis.

Will a knee replacement get rid of osteoarthritis? ›

Unfortunately, knee replacement surgery does not cure arthritis. Although it can correct the damage caused by arthritis and relieve the pain associated with the condition, it cannot make the arthritis go away.

What is the safest arthritis medication? ›

Methotrexate is widely regarded as one of the safest of all arthritis drugs, though it carries some potential downsides. Gastrointestinal symptoms such as nausea and vomiting are its most frequent side effects.

What medications make osteoarthritis worse? ›

Fluoroquinolone antibiotics, statins, and aromatase inhibitors are among the medications that most commonly cause joint or muscle pain. If you think that a medication you take is causing joint or muscle pain, talk with your healthcare provider.

Can tramadol help osteoarthritis? ›

Tramadol is as an alternative treatment option for osteoarthritis (OA) of the knee and hip for people who have failed treatment with acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) or cannot take these medications. Tramadol can also be used in conjunction with acetaminophen or NSAIDs.

What are the options for severe arthritis on the knee? ›

Knee arthritis typically makes the knee joint painful and stiff. Consulting with a physical therapist can increase the strength of the muscles supporting the knee and reduce pain. Therapists can use ice and heat, electrical nerve stimulation and other therapies to increase blood flow to the knee.


1. How to Fix Knee Pain for Good (AT HOME!)
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2. How To Treat Knee Pain Without Exercises (At Home)
(Bob & Brad)
3. Knee Pain Relief Tips Including Hot and Cold Therapy
4. Hip and knee surgery webinar
(Benenden Hospital)
5. 5 Knee Pain Physiotherapy Exercises, Knee Osteoarthritis, Knee Pain Relief Treatment, KNEE OA
(Sukoon physical therapy)
6. Acupuncture for Knee Pain


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